Endocrine Abstracts

Introduction: Hajdu Cheney Syndrome (HCS) is a rare genetic autosomal dominant disorder affecting multiple organ systems, characterized by distinctive facial features, acroosteolysis and severe osteoporosis. In a limited number of cases, the disease appears in association with polycystic kidney disease (PKD) or Crohn’s disease (CD). Splenomegaly has also been reported. Heterozygous gain-of-function mutations in NOTCH2 gene have been confirmed to be the cause of H...

Introduction: Tertiary hyperparathyroidism can be developed in cases of persistent or non-curable secondary hyperparathyroidism or in any other case of long-standing hypocalcemia that leads to the autonomous function of at least one parathyroid gland. We present a case of a man with tertiary hyperparathyroidism and excessive maxilla swelling and extensive bone lesions.Presentation: A 32 years old man, with chronic renal failure on dialysis for twelve yea...

Introduction: Thyrotropin (TSH) secreting pituitary adenomas (TSHomas) are very rare and account for less than 2% of all pituitary adenomas. They present with elevated levels of fT4 and normal to high levels of TSH. About 25% of TSHomas co-secrete other anterior pituitary hormones. Growth hormone (GH) is the most commonly co-secreted hormone, followed by prolactin (PRL) and gonadotropins. Herein, we report a case of pituitary adenoma with simultaneous secretion of TSH and GH.<...

Introduction: Adrenal cystic lesions are rare. Differential diagnoses include pseudocysts, echinococcal cysts, hemangiomas, cystic pheochromocytomas, adrenal hematomas and lymphangiomas. We present here a rare case of an adrenal lymphangioma.Case report: A 35-year old man was referred to our department for investigation of a right adrenal cystic mass, incidentally found during an abdominal ultrasound. The patient was completely asymptomatic and had a med...

Background: Levothyroxine (LT4) is one of the most prescribed drugs worldwide. Once started, about 90% of patients continue LT4 treatment long-term.Aim of the study: To evaluate the necessity of long-term thyroxine supplementation and to determine the prognostic factors that could identify which patients may discontinue LT4 treatment.Design and methods: LT4 replacement therapy was paused for at least six weeks in all patients conse...

Background and aims: Gestational diabetes (GD) is closely related to unbalanced zinc (Zn) and cooper (Cu) serum levels. The aim of this study was to investigate serum zinc and cooper levels in relation to the metabolic profile, and the impact on fetal development in a cohort of gestational diabetes GD(N) neonates and their mothers GD(M) compared to normal pregnancies.Material and Methods: Prospective controlled study in a tertiary Academic medical center...

Background: Intestinal metaplasia (IM) of the gastric mucosa is a relatively frequent precancerous lesion. The aim of the study was to assess the prevalence and the kind of IM and also to find parameters that could predict the presence of IM in gastric neuroendocrine neoplasms type 1 (GNEN1).Methods: Fifty-nine (45 females) patients with GNEN1 were retrospectively studied. All patients included in the study had positive parietal-cell antibodies. All pati...

Introduction: Cynicism (or cynical distrust) is described as a state of mind and belief that most people are selfish. Cynicism is an attitude characterized by general distrust of the motives of others, and some experts describe it as a form of chronic anger. Negative emotions, especially cynicism, may be harmful to physical health.Aim: The assessment of cynicism in pregnant women with common endocrine diseases.Subjects – Metho...

Introduction: Acromegaly is a systematic disease with charecteristic clinical features, which is due to GH hypersecretion mainly from pituitary adenomas and in rare cases it can be due to ectopic GHRH and GH hypersecretion. Sometimes localizing the source of hypersecretion is difficult. Here we present a case of a woman with acromegalic phenotype and empty sella.Presentation: A 47 years old woman referred to our department after recent onset of high bloo...

Introduction: IgG4 Related Hypophysitis (IgG4-RH) is a newly recognized form of hypophysitis. It usually appears as part of IgG4-Related Disease (IgG4-RD), an immune mediated disease, with manifestations in many organs. Isolated hypophysitis without other IgG4-RD manifestations is rare.Presentation: A 64 years old female referred to our department for further investigation of a 9 month history of fatigue, muscle weakness, recurrent episodes of right temp...